[Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation.] Zeitschrift fur Rheumatologie [Z Rheumatol] Journal article | | Title | [Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation.] | | Author(s) | Gadola SD | | Institution | Division of Infection, Inflammation & Immunity, Southampton General Hospital, School of Medicine, University of Southampton, UK, MP811 Tremona Road, SO16 6YD, Southampton, Grossbritannien, s.gadola@soton.ac.uk. | | Source | Z Rheumatol 2009 Oct 16. | | Abstract | The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes. | | Language | GER | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19830437 |
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